The incident occurred around 4pm on December 12 when a black Yamaha motorbike collided with a red Mini Cooper on the London Road, near to the junction of Montrose Avenue.
The motorcyclist, a man who was in his forties, tragically died at the scene.
His next of kin have been informed.
Investigating officer, Detective Sergeant Darren Brown, of the Serious Collisions Investigation Unit, said: “My thoughts remain with the family and friends of the motorcyclist at this difficult time.
“We are carrying out an investigation into this incident and are appealing for any witnesses to please come forward.
“Further, if any motorists have dash-cams and were in the area around the time of this incident, I’d please ask you to check any footage in case it may have captured something that could assist the investigation.
“Anyone with information can contact police by calling 101 or making a report online, quoting reference 43210560662.”
No arrests have been made as a result of this incidents, Thames Valley Police confirmed.